How to beat all Marvel's Spider-Man 2 Mysteriums

Spider Man 2 Mysteriums
(Image credit: Sony Interactive Entertainment)

The Spider-Man 2 Mysteriums are combat challenges found all over the city, and while getting a gold medal in any of them is a challenge, getting gold in all of them a real task that'll require a superior Spider-Man,.

Completing all Mysteriums will eventually lead to a confrontation with Mysterio himself, and a reward. To that end, here's how to find and beat every Mysterium in Marvel's Spider-Man 2, which will unlock one of the many Spider-Man 2 suits upon completion.

This being one of the collectibles with a story thread running through it, there are spoilers for the Mysterium plotline if you skip to the end, so be warned.

All Mysterium locations in Marvel's Spider-Man 2

(Image credit: Sony Interactive Entertainment)

This Mysterium locations map for Marvel's Spider-Man 2 will help you find them all. The numbering is purely a reference as you can do them in any order apart from the final confrontation marked in green, which only unlocks when everything else is done.

  1. Under Construction: Defeat 20 enemies within the time limit while avoiding poison gas.
  2. Everyone's a Critic: Defeat 30 enemies within the time limit while avoiding Mysterio's giant fist.
  3. Prison Break: Defeat 20 enemies within the time limit while Mysterio attempts to shield them.
  4. The Invisible Enemy: Use finishers on 6 invisible enemies within the time limit .
  5. Punch Your Ticket: Defeat 6 Brutes within the time limit while avoiding sudden trains.
  6. Fight On Time: Use finishers on 6 enemies within the time limit while avoiding lasers.
  7. Road Rage: Defeat 20 enemies without taking damage, and avoiding speeding cars.
  8. Grave Decision: Defeat 3 rounds of enemies (and Mysterio) without taking damage.
  9. Fear of Heights: Knock 15 enemies off the map within the time limit.
  • Mysterio final boss: Confront Mysterio directly for a boss fight. This only unlocks when all Mysteriums have been completed, and cannot be replayed.

Some Mysteriums are a lot harder than others, and the fact that you can only use Miles to beat them means that those who prefer venom powers to electric blasts will have to learn to adapt quickly.

Once they're all beaten, you'll have a confrontation with the mysterious Mysterio – who's extra mysterious this time because his alter-ego Quentin Beck is supposedly rehabilitated. However, first you've got to deal with the various Mysterium challenges – which we'll show you how to do now.

Under Construction Mysterium

Under Construction Mysterium Spider-Man 2

(Image credit: Sony Interactive Entertainment)
  • Objective: Defeat 20 enemies within the time allocated while avoiding poison gas.
  • Gold Medal conditions: Complete in 1:00 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Ricochet Web (Gadget)
    • Damage (Suit Tech upgrade chain)
    • Mega Venom Blast: Overcharge, Thunder Burst: Static Boom (Skills)
    • Reverse Flux, Thunder Burst (Abilities)

This is one of the hardest Mysteriums, as while taking down 20 enemies is relatively easy, doing it in less than a minute for the gold medal is hard. Because all the enemies are mostly weak, focus on big, area-covering attacks provided by your Venom powers and Gadgets (like the ricochet web) that trigger very quickly and can instantly pin a full-health enemy to the wall. Finishers aren't good here as they take too long to do and only deal with one enemy at a time. Focus on speed and large scale attacks, rather than major strikes on a single target. Mathematically speaking, you have to average defeating at least one opponent every three seconds - any less, and you won't hit gold.

Everyone's a Critic Mysterium

Everyone's a Critic Mysterium Spider-Man 2

(Image credit: Sony Interactive Entertainment)
  • Objective: Defeat 30 enemies within the time allocated while avoiding Mysterio's giant fist.
  • Gold Medal conditions: Complete in 1:45 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Web Grabber (Gadget)
    • Damage/Health (Suit Tech upgrade chains)
    • Fired Up (Skills)
    • Reverse Flux, Thunder Burst (Abilities)

This is one of the easier Mysterium Challenges with a pretty simple aim to take out a number of enemies in the time limit, made only slightly more dangerous by a mid-challenge map change and moments where Mysterio's fist explodes up from the ground to hit you. That's easy to avoid though by simply using a Web-Strike on any enemy outside of its radius to zip out of the way. A smart player can also use it to defeat opponents as well - try dropping a Web Grabber on the danger zone right before the fist emerges, so all the enemies are pulled in and smashed by the giant hand.

Prison Break Mysterium

Prison Break Mysterium Spider-Man 2

(Image credit: Sony Interactive Entertainment)
  • Objective: Defeat 20 enemies within the time allocated while Mysterio attempts to shield them.
  • Gold Medal conditions: Complete in 2:15 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Web Shooters, Ricochet Web (Gadgets)
    • Focus (Suit Tech upgrade chains)
    • Fired Up, Amped, Web Whip (Skills)
    • Venom Punch, Thunder Burst (Abilities)

The Prison Break Mysterium is another challenge simply about dealing with an enemy horde, but now Mysterio himself makes gets involved by using his powers to add an unbreakable shield to enemies. To deal with him as quickly as possible, the moment the shields come up look for a telltale red exclamation point to see where he's flying about, Web Strike at him with Triangle, then immediately use a finisher to instantly get rid of him He'll come back repeatedly, so make sure you always have a finisher banked for when he does.

The Invisible Enemy Mysterium

Spider Man 2 The Invisible Enemy Mysterium

(Image credit: Sony Interactive Entertainment)
  • Objective: Use finishers on 6 invisible enemies within the time allocated.
  • Gold Medal conditions: Complete in 2:10 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Web Grabber, Sonic Burst (Gadgets)
    • Focus (Suit Tech upgrade chains)
    • Fired Up, Air Swap (Skills)
    • Galvanize (Abilities)

Surprise! Your opponents keep turning invisible in The Invisible Enemy Mysterium. But that's not as much of an issue as you'd think. Try to stay in the air here for a couple of reasons - firstly, the only thing that can hit then there are ranged weapons, which always give you a warning and, secondly, the Aerial Focus Suit Tech power means you'll charge your finishers much more quickly in the sky. Keep yanking or launching enemies up to that level, then wail on them until you can use your next finisher.

Punch Your Ticket Mysterium

Spider Man 2 Punch Your Ticket Mysterium

(Image credit: Sony Interactive Entertainment)
  • Objective: Defeat 6 Brutes within the time allocated while avoiding sudden trains.
  • Gold Medal conditions: Complete in 2:00 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Web Grabber (Gadgets)
    • Damage (Suit Tech upgrade chains)
    • Directional Yank/Heavy Lifting (Skills)
    • Reverse Flux (Abilities)

The Punch Your Ticket Mysterium adds trains to run you over but gets much easier when you realise the enemies don't try to avoid the trains at all, which destroy them instantly. Winning this then simply becomes a matter of luring everyone into their path, then dodging out of the way. If you're feeling cheeky, you can even use the Web Grabber or Directional Yank/Heavy Lifting skills to move them into the train's path, but it's easy enough to kite them without it.

Fight On Time Mysterium

Spider Man 2 Fight On Time Mysterium

(Image credit: Sony Interactive Entertainment)
  • Objective: Use finishers on 6 enemies within the time allocated while avoiding lasers.
  • Gold Medal conditions: Complete in 3:30 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Upshot (Gadgets)
    • Focus/Health (Suit Tech upgrade chains)
    • Fired Up, Amped, Air Swap (Skills)
    • Venom Dash (Abilities)

The Fight On Time Mysterium is another challenge where air combat is key to winning, using the Aerial Focus and Air Swap powers to rack up focus safely in the sky. The giant laser that periodically shoots at you during this challenge also seems to struggle to lock onto Miles when he's in the air, firing at the ground below you instead.

Road Rage Mysterium

Spider Man 2 Road Rage Mysterium

(Image credit: Sony Interactive Entertainment)
  • Objective: Defeat 20 enemies without taking damage, and avoiding speeding cars.
  • Gold Medal conditions: Do not get hit once
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Ricochet Web, Web Grabber (Gadgets)
    • Focus/Damage (Suit Tech upgrade chains)
    • Mega Venom Blast: Recharge, Fired Up, Gadget Resupply (Skills)
    • Chain Lightning, Thunder Burst (Abilities)

The Road Rage Mysterium is tricky one as you can't take any damage, so play defensively. Like in the Train-based Mysterium, you can use the cars to run over oblivious enemies, but it's harder to set up here, as there are a lot of guns and more enemies, creating a busier environment. Staying in the sky will help, and target ranged enemies as a priority – it's all too easy to get clipped by an assault rifle bullet.

Grave Decision Mysterium

Spider Man 2 Grave Decision Mysterium

(Image credit: Sony Interactive Entertainment)
  • Objective: Defeat 3 rounds of enemies (and Mysterio) without taking damage.
  • Gold Medal conditions: Do not get hit once
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • Web Grabber, Sonic Burst (Gadgets)
    • Damage/Focus (Suit Tech upgrade chains)
    • Web Whip, Directional Yank (Skills)
    • Reverse Flux (Abilities)

The Grave Decision Mysterium would be a straightforward "no damage" enemy clearing challenge, if not for one thing – Mysterio himself keeps showing up to attack you, floating about the arena and using ranged projectiles. There's a giant skull that you can throw back, and a fast-firing laser that's harder to dodge or deal with. Like in the Prison Break, the best thing you can do is have a finisher banked for when he shows up, immediately web strike to him and use it to take him out. For the other enemies, focus on disarming them as there's a lot of gun-wielding enemies, and use abilities and gadgets that knock them into the chasms around the arena for easy kills.

Fear of Heights Mysterium

Spider Man 2 Fear of Heights Mysterium

(Image credit: Sony Interactive Entertainment)
  • Objective: Knock 15 enemies off the map within the time allocated.
  • Gold Medal conditions: Complete in 1:30 or less
  • Recommended Suit Tech/Gadgets/Skills/Abilities:
    • None (see below)

Fear of Heights is by far the easiest Mysterium if you have the methodology down. The goal is to knock 15 enemies off the map so simply do a big jump off the edge, then start holding Triangle to web-yank enemies into the open space one by one, dodging whenever you need to. You can complete this safely and easily in under 40 seconds this way – no gadgets, skills, or special abilities required.

Spider-Man 2 Mysterio boss fight

Spider Man 2 Mysterio boss fight

(Image credit: Sony Interactive Entertainment)

After completing all the Mysteriums, you'll confront Mysterio back at Coney Island. This leads to a multi-stage boss fight where you'll deal with the villain's minions and swing through an obstacle course to fight the villain himself – first a single version, then multiple incarnations that swarm you.

This is a boss fight that's big on aerial combat – if you've got some skill points and tech parts, you'll want all the skills on the left side of the shared Spider-skill tree, like Air Swap and Leap Off Bounce, and rack up some Focus skills for taking out the incarnations quickly. It's not a hard boss fight though, just stay evasive, and you'll come out the other side!

After completing this fight, you'll still be able to replay the Mysteriums whenever you want, and you'll get the Smoke and Mirrors suit for Miles.

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Joel Franey
Guides Writer

Joel Franey is a writer, journalist, podcaster and raconteur with a Masters from Sussex University, none of which has actually equipped him for anything in real life. As a result he chooses to spend most of his time playing video games, reading old books and ingesting chemically-risky levels of caffeine. He is a firm believer that the vast majority of games would be improved by adding a grappling hook, and if they already have one, they should probably add another just to be safe. You can find old work of his at USgamer, Gfinity, Eurogamer and more besides.